Bioconjugation Process Services
Bioconjugation Process Platform Overview
Intellective Bio provides an integrated Bioconjugation Process Development Platform, offering end-to-end services for ADCs, AOCs, DACs, APCs, ISACs, RDCs, etc.. Our services span early-stage research, process development, optimization, technology transfer and process characterization.
Leveraging advanced conjugation technologies and extensive expertise, the platform helps reduce production costs, shorten development timelines, and accelerate regulatory submissions and commercialization for the global clients.
Conjugation Technology Platform
Intellective Bio has established a comprehensive Bioconjugation Technology Platform, including but not limited to the following conjugation approaches: the traditional random conjugation, such as native lysine and cysteine conjugation, and the site-specific conjugation, such as enzyme-mediated conjugation involved in Endo S2, mTGase, Sortase A, etc., engineering cysteine conjugation, unnatural amino acid conjugation, disulfide rebridging conjugation, etc. For each conjugation technology, tailored process routes are designed.
Process route for native lysine
Mab
Conjugation
Quenching
UF&DF
DS
Process route for native cysteine
Mab
Reduction
Conjugation
Quenching
UF&DF
DS
Process route for sortase a-mediated
Mab
Conjugation
AC
CEX
UF&DF
DS
Process route for endoglycosidase-mediated
Mab
UF&DF
Remodeling
Conjugation
AC/CEX
UF&DF
DS
Process route for engineering cysteine
Mab
Reduction
UF&DF
Oxidation
Conjugation
Quenching
UF&DF
DS
Conjugation Process
Both volume-dependent and independent process parameters that impact critical quality attributes (CQAs) are systematically optimized to identify critical process parameters (CPPs) and define their acceptable ranges. The platform enables stepwise scale-up from milligram to gram and kilogram levels, ensuring final process confirmation and robustness.
Carriers and Toxins
in Bioconjugation
Within our bioconjugation platform, Intellective Bio works with a wide range of carriers, including: Mab, BsAb, scFv, sdAb, Nbs, fusion protein, peptide, etc..
We also integrate diverse toxins, such as: microtubule inhibitors, topoisomerase inhibitors, DNA alkylating agents, oligonucleotides, linkers, polyethylene glycol, immunostimulants, chelators, etc..
Toxins:
Topoisomerase Inhibitor
Microtubule Inhibitor
Oligonucleotide
PEG
Linker
Carriers:
Mab
BsAb
scFv
Fc-fusion Protein
Laboratory and Manufacturing
Equipment
Laboratory
Filling Room
Lyophilization Room
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