Cell Line Development & Cell Culture

Cell Line

The cell line is the vital link between lead molecule discovery and biologic process development. A stable, high-performing cell line enables the development of robust, scalable, and cost-effective manufacturing processes. With a mature cell engineering technology platform and experience from more than 100 completed projects spanning most types of therapeutic proteins, Intellective Bio is the ideal partner for your mammalian cell culture projects. We have multiple CHO (Chinese Hamster Ovary) cell lines and various expression systems to satisfy the diverse requirements of our partners.

Cell Line Development

Establishing a sustainable process begins with cell line development that is built on speed, flexibility, and performance. Our services include gene construction, stable transfection, and clone screening and evaluation.

Why Us?

Simple cell line commercial licensing agreements that avoid royalties, with use flexibility and limited restrictions
Extensive experience in developing and utilizing various host cells, including CHO-K1, CHO-S, CHO-DG44, and other third-party developed cell lines, encompassing expression systems like GS-, DHFR-, fut-, to meet the functional requirements of different antibodies or fusion proteins
Special expression systems, including GS-, DHFR-, fut-, which meet the functional requirements of different antibodies and fusion proteins
Automated high-throughput clone plating system that contributes to efficient cell line construction and selection of top clones, enabling a timeline of 11 weeks from molecule to top clone selection
Cell imaging to verify monoclonicity, which is critical for regulatory success
GMP cell banking
Seamless interaction with in-house experts in cell line stability and cell culture process development ensures a robust cell line and reproducible, scalable bioreactor fed-batch titers, typically ranging from 2.5 to 8.0 g/L